Neurovascular development

NRP1 function and targeting in neurovascular development and eye disease

Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools for experimental investigation of NRP1 func...

Astroglial Integrins in the Development and Regulation of Neurovascular Units

In the neurovascular units of the central nervous system, astrocytes form extensive networks that physically and functionally connect the neuronal synapses and the cerebral vascular vessels. This astrocytic network is thought to be critically important for coupling neuronal signaling activity and energy demand with cerebral vascular tone and blood flow. To establish and maintain this elaborate ...

The Bimodal Nature of Neurovascular Coupling

Neurons, by virtue of their complex and continuously changing signaling roles in brain, must be able to regulate access to energy in order to maintain their ability to communicate meaningful frequency-encoded information. This is accomplished by release of neurotransmitters to astrocytes that in turn signal the vascular system to increase cerebral blood flow (CBF). This process has been termed ...

Neurovascular Imaging

but also well-controlled manipulations (Allegra Mascaro et al., 2010; Kleinfeld et al., 2011) crucial for testing causality rather than simply establishing a correlation between measurement parameters (that does not automatically imply that one of the parameters drives the other). Moreover, the present collection of papers reaches well beyond the current state of knowledge, defining important q...

Stroke and neurovascular protection.